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Louis A. Kazal Papers

Notifications

Held at: Science History Institute Archives [Contact Us]315 Chestnut Street, Philadelphia, PA 19106

This is a finding aid. It is a description of archival material held at the Science History Institute Archives. Unless otherwise noted, the materials described below are physically available in their reading room, and not digitally available through the web.

Overview and metadata sections

Call Number:
033
Repository:
Science History Institute Archives
Extent:
4.9 linear feet (9 boxes.)
Language:
English
Preferred Citation:
Item Description, Box Number, Folder Number, Louis A. Kazal Papers, 1930-2002, Science History Institute Archives, Philadelphia, Pennsylvania.
Date:
1930-2002 (inclusive) and 1942-1981 (bulk)
Creator:
Kazal, Louis A.
Form:
Archival materials
Abstract:
Correspondence, publications, reprints, grant applications, presentation materials, laboratory notes, and photographs belonging to American chemist Louis A. Kazal. This collection concerns Kazal's work with blood plasma protein fraction. Box 9 contains the addenda to the collection, which concerns Kazal's earlier work at the American pharmaceutical company Merck Sharp & Dohme Corporation.

Louis Anthony Kazal graduated from Seton Hall College in South Orange, New Jersey (1935), and received his Ph.D. from Rutgers University in New Brunswick, New Jersey (1940). He was hired by Merck Sharp & Dohme Corporation as a research biochemist where he remained until 1957. In 1957, Kazal joined the staff of the Cardeza Foundation at Jefferson Medical College in Philadelphia, Pennsylvania. He retired from Jefferson Medical College as a Professor of Physiology and an Associate Professor of Medicine in 1978.

Sources

Louis A. Kazal Papers, Science History Institute Archives, Philadelphia, Pennsylvania.

The Louis A. Kazal Papers contain the personal papers of American chemist Louis A. Kazal. The collection is arranged into the following two series:

  1. Louis A. Kazal Files
  2. Merck Sharp & Dohme Addenda

The Louis A. Kazal Papers were donated to the Science History Institute (formerly the Chemical Heritage Foundation) by Louis A. Kazal in two installments: 2004 and 2011.

The Louis A. Kazal Papers were processed by Marguarita Schmidt. The addenda to the Louis A. Kazal Papers were processed by Andrew Mangravite in 2017. The finding aid was encoded into EAD by Kenton G. Jaehnig in 2021.

There are no other known archival collections created by Louis A. Kazal at the time of processing.

Organization
Subject

Publisher
Science History Institute Archives
Finding Aid Author
Finding aid created by Andrew Mangravite and encoded into EAD by Kenton G. Jaehnig.
Finding Aid Date
2017
Access Restrictions

There are no access restrictions on the materials.

Use Restrictions

The Science History Institute holds copyright to the Louis A. Kazal Papers. The researcher assumes full responsibility for all copyright, property, and libel laws as they apply.

Collection Inventory

Series Description

This series contains the Louis A. Kazal Files of the Louis A. Kazal Papers. Arranged in its original order, this series consists of one hundred thirty-five files in Boxes 1-8. These files contain correspondence, publications, reprints, laboratory notes, presentation materials, and photographs belonging to Louis A. Kazal.

Blood Plasma Protein Fraction - Sections I-XI, undated.
Box 1 Folder 1
Blood Plasma Protein Fraction - Sections XII-XXIII, undated.
Box 1 Folder 2
Addendum to Blood Plasma (Folder 1 of 2.), undated.
Box 1 Folder 3
Addendum to Blood Plasma (Folder 2 of 2.), undated.
Box 1 Folder 4
Reprints (re: Plasma Protein and Separation into Fractions.), undated.
Box 1 Folder 5
Denkewalter, R. G. and Louis A. Kazal. "Pharmaceutical and Biological Products", undated.
Box 1 Folder 6
Kazal, Louis A. - Curriculum Vitae, undated.
Box 1 Folder 7
Correspondence (re: Donation of papers to the Chemical Heritage Foundation, Philadelphia, Pennsylvania.), undated.
Box 1 Folder 8
Cardeza Foundation, Jefferson Medical College, Philadelphia, Pennsylvania - Progress Reports, 1956-1978.
Box 2 Folder 1
Grant Number HE03544-02, 1957-1959.
Box 2 Folder 2
Grant Number HE03544-03 - Progress Report, undated.
Box 2 Folder 3
Louis A. Kazal Presentations, 1965-1966.
Box 2 Folder 4
Grant Number HE03544-04, 1957-1962.
Box 2 Folder 5
Grant Number HE03544-05, 1961.
Box 2 Folder 6
Grant Number HE03544-06, 1962-1963.
Box 2 Folder 7
Grant Number HE03544-07, 1963.
Box 2 Folder 8
Grant Number HE03544-08, 1964.
Box 2 Folder 9
Grant Data, 1966.
Box 2 Folder 10
Grant Number HE03544-09, 1967.
Box 2 Folder 11
Grant Number HE03544-10, 1968.
Box 2 Folder 12
Rheumatoid Arthritis Joint Fluid, 1969.
Box 2 Folder 13
Esterase - Glycine-Saturated Plasma, undated.
Box 2 Folder 14
Spectrophotometric Coagulation - Federation of American Societies for Experimental Biology, 1973.
Box 2 Folder 15
Rheumatoid Arthritis - Smukler, undated.
Box 2 Folder 16
Ribonuclease - Factor XII, undated.
Box 2 Folder 17
Grant Application, 1973.
Box 2 Folder 18
Erythropoietin - grant application, 1977.
Box 2 Folder 19
Erythropoietin - slide charts, undated.
Box 2 Folder 20
Erythropoietin Inhibition Paper, undated.
Box 2 Folder 21
Erythropoietin - current research, 1977-1978.
Box 2 Folder 22
Renal Lipid Inhibition - specificity studies, undated.
Box 3 Folder 1
Ribonuclease Research, 1975.
Box 3 Folder 2
Inhibition - F XII-Activation RNase Inhibitors, undated.
Box 3 Folder 3
Grant Application - Grannis, undated.
Box 3 Folder 4
Grant Number 08137 - American College of Gastroenterology, undated.
Box 3 Folder 5
Louis A. Kazal Talks, 1957-1958.
Box 3 Folder 6
Literature - NH plasma fractionation, undated.
Box 3 Folder 7
Louis A. Kazal Talks, 1959-1963.
Box 3 Folder 8
Reports, 1964.
Box 3 Folder 9
Fibrinogen - seminar, undated.
Box 3 Folder 10
Federation of American Societies for Experimental Biology, 1965.
Box 3 Folder 11
National Institute of Health Site Visit, 1966 June.
Box 3 Folder 12
Clinical Conference - Gamma globulin (handwritten), undated.
Box 3 Folder 13
Clinical Conference - Macroglobulinemia (handwritten), undated.
Box 3 Folder 14
Federation of American Societies for Experimental Biology, 1964.
Box 3 Folder 15
Federation of American Societies for Experimental Biology, 1965.
Box 3 Folder 16
Federation of American Societies for Experimental Biology, 1966.
Box 3 Folder 17
National Institute of Health - summer student research, 1965.
Box 3 Folder 18
Ribonuclease vs. Pancreatic Inhibitor Studies, undated.
Box 4 Folder 1
Clinical Conference - Lipoproteinemia (handwritten), 1967 May 10.
Box 4 Folder 2
Cardeza Foundation Report (handwritten), 1969 January 9.
Box 4 Folder 3
Erythropoietin Inhibitor - American Society of Biological Chemists talk, 1971.
Box 4 Folder 4
Ribonuclease Paper - Naples, undated.
Box 4 Folder 5
Erythropoietin - Proc. Soc., 1968 June 3.
Box 4 Folder 6
Esterase Activity - American Chemical Society paper, 1968 September.
Box 4 Folder 7
Artificial Substrates for Factor VIII - Federation of American Societies for Experimental Biology, 1968.
Box 4 Folder 8
Esterase Activation in Human Plasma - Federation of American Societies for Experimental Biology, 1968.
Box 4 Folder 9
Separation of a Renal Inhibitor - Federation of American Societies for Experimental Biology, 1968.
Box 4 Folder 10
E-Inhibitor Physiology Soc., 1971.
Box 4 Folder 11
Glycine Precipitated in Plasma - International Society on Thrombosis, Washington, D.C., 1972 August 22.
Box 4 Folder 12
Federation of American Societies for Experimental Biology, 1973.
Box 4 Folder 13
Presentations, 1971-1973.
Box 4 Folder 14
Ribonuclease (Mostly handwritten.), undated.
Box 4 Folder 15
Progress Report - Non-Thrombogenic Cannula, 1970 October 21.
Box 4 Folder 16
Hagman Factor, undated.
Box 4 Folder 17
Crystalline Ribonuclease Inhibition of Factor XII - AHA, Miami, Florida, 1976 November 17.
Box 4 Folder 18
Hagman Factor - American Society of Biological Chemistry, 1974 June 3.
Box 4 Folder 19
Lack of Ribonuclease Inhibition of Ellagic Acid - Federation of American Societies for Experimental Biology, 1974 June 19.
Box 4 Folder 20
Cardeza Foundation Seminar, 1977.
Box 4 Folder 21
Federation of American Societies for Experimental Biology - data and paper, 1974 June 19.
Box 4 Folder 22
American Society of Biological Chemists, 1974 June 3.
Box 4 Folder 23
Federation of American Societies for Experimental Biology, 1974.
Box 4 Folder 24
Effects of Calcium on Ellagic Acid Activation (handwritten), undated.
Box 4 Folder 25
5th Philadelphia Workshop on Hemostasis and Thrombosis, Philadelphia, Pennsylvania, undated.
Box 5 Folder 1
Dr. Milstone, undated.
Box 5 Folder 2
Chapter Correspondence, 1978-1980.
Box 5 Folder 3
Correspondence - Leandro Tocantinis book, undated.
Box 5 Folder 4
Special Correspondence I, undated.
Box 5 Folder 5
Special Correspondence II, undated.
Box 5 Folder 6
Correspondence, 1980-1981.
Box 5 Folder 7
Special Correspondence III, undated.
Box 5 Folder 8
Correspondence, 1979.
Box 5 Folder 9
Correspondence, 1975-1976.
Box 5 Folder 10
Project Site Visit - Cleveland, Ohio, 1976.
Box 5 Folder 11
Correspondence - Jefferson Medical College, undated.
Box 5 Folder 12
Correspondence - Jefferson Medical College, 1983.
Box 5 Folder 13
General Correspondence, 1974.
Box 5 Folder 14
General Correspondence, 1973.
Box 5 Folder 15
General Correspondence, 1972.
Box 5 Folder 16
General Correspondence, 1970-1971.
Box 5 Folder 17
General Correspondence, 1967-1969.
Box 5 Folder 18
General Correspondence, 1965-1966.
Box 5 Folder 19
General Correspondence, 1963-1965.
Box 5 Folder 20
Correspondence, 1960-1962.
Box 6 Folder 1
Correspondence, 1957-1959.
Box 6 Folder 2
Correspondence, 1956.
Box 6 Folder 3
Correspondence - pre-1956, undated.
Box 6 Folder 4
Merck Sharp & Dohme, undated.
Box 6 Folder 5
Related Materials

See also Box 9.

Correspondence, 1950-1955.
Box 6 Folder 6
Dr. Jim D. Boston, undated.
Box 6 Folder 7
New York Academy of Sciences, New York, New York, undated.
Box 6 Folder 8
Correspondence - Pavlowski, undated.
Box 6 Folder 9
C. Sparks - references, undated.
Box 6 Folder 10
Blood Coagulant Activity of Human Gastric Juice, undated.
Box 6 Folder 11
American Journal of Gastroenterology, 1965.
Box 6 Folder 12
Personnel, 1966.
Box 6 Folder 13
Grune and Stratton, Incorporated, 1976.
Box 6 Folder 14
University of Rome, Rome, Italy, 1970.
Box 6 Folder 15
Artificial Substrates (patent), undated.
Box 6 Folder 16
Academic Leave, 1975-1976.
Box 6 Folder 17
Association of Clinical Scientists, undated.
Box 6 Folder 18
Blood Lectures - Osteopathic, undated.
Box 6 Folder 19
AHA Council Delegate, 1972 November 16.
Box 6 Folder 20
Robert A. Hartie - lysozyme, undated.
Box 6 Folder 21
William P. Boger - antithrombin, undated.
Box 6 Folder 22
Index of Cervicitis, undated.
Box 7 Folder 1
Prostaglandins (correspondence), undated.
Box 7 Folder 2
Jordan, M. "Study of Platelets by Light Scattering", undated.
Box 7 Folder 3
General Note

Includes two black and white photographs.

Trypsin inhibitor research, undated.
Box 7 Folder 4
Fibrinogen Precipitation and Purification - Kazal and Miller I, undated.
Box 7 Folder 5
Fibrinogen Precipitation and Purification - Kazal and Miller II, undated.
Box 7 Folder 6
Fibrinogen Publication (Folder 1 of 3.), undated.
Box 7 Folder 7
Fibrinogen Publication (Folder 2 of 3.), undated.
Box 7 Folder 8
Fibrinogen Publication (Folder 3 of 3.), undated.
Box 7 Folder 9
Photographs of Figures for Paper, undated.
Box 7 Folder 10
American Chemical Society Paper - Washington, D.C., 1962.
Box 7 Folder 11
Correspondence (re: Fibrinogen.), undated.
Box 7 Folder 12
Precipitation of Fibrinogen from Plasma by Glycine - experimental data, undated.
Box 8 Folder 1
Lab Notes - Precipitation of fibrinogen (Folder 1 of 2.), undated.
Box 8 Folder 2
Lab Notes - Precipitation of fibrinogen (Folder 2 of 2.), undated.
Box 8 Folder 3
Lab Notes - AH6 activity in fibrinogen fraction (Folder 1 of 2.), undated.
Box 8 Folder 4
Lab Notes - AH6 activity in fibrinogen fraction (Folder 2 of 2.), undated.
Box 8 Folder 5
Louis A. Kazal Reprints, 1942-1964.
Box 8 Folder 6
Louis A. Kazal Reprints, 1965-1978.
Box 8 Folder 7
Gadarowki, J. - thesis (Fifty percent of the research conducted on Ribonuclease-Hagman factor activation.), undated.
Box 8 Folder 8
General Comments (re: Research at S and D.), 1943-1944.
Box 9 Folder 1

Series Description

This series contains the Merck Sharp & Dohme Addenda of the Louis A. Kazal Papers. Arranged in its original order, this series consists of fifteen files in Box 9. These files contain correspondence, progress reports, and reprints supplemented by a running commentary from Louis A. Kazal explaining the significance of the work and placing it in historical perspective.

Research programs; Horse brain thromboplastin; Hyperglycemic factor; Pancreatic digests (Incl. reprints.), 1940-1942.
Box 9 Folder 2
Synthetic anticoagulants; Reitz paper (Reitz, H. and H. Cords.) "Uber Sulfurierte Protein und Ihre Eigenschaften als Blutantikoagulantien," Biochemische Zeitschrift, Bd. 321, S.414-420, 1951.
Box 9 Folder 3
Anticoagulant-Pancreatic Trypsin Inhibitor (Kazal trypsin inhibitor); Protein crystallization anomalies, 1950, 1951.
Box 9 Folder 4
Kazal trypsin inhibitor (Dr. M. Laskowski Sr.'s proposal.); Correspondence with M. Laskowski Sr. and Jr. (Incl. reprints.); Pancreatitis-SPINK 1; Requests for Kazal inhibitor; Pancreatic anticoagulant-trypsin inhibitor, 1949-2002.
Box 9 Folder 5
Correspondence with Dr. Lewis J. Green (Incl. reprints.); Correspondence with Dr. Philip J. Burke, Eli Lilly Company (Incl. reprints.); Correspondence with Edmund W. Cerwinsky, Indiana University School of Medicine, Indianapolis, Indiana; Correspondence with Edward L. Grinnan, Eli Lilly Company, 1966-1977.
Box 9 Folder 6
M. Kunitz (reprints); Special Projects: MSD Incorporated - Biological Development (Armed Forces liquid plasma); 1954 Organizational Changes, 1942-1977.
Box 9 Folder 7
Manager-Technical Information; Technical Assistant to Medical Director; Vitamin B-12 Projects; Jefferson Medical College, Philadelphia, Pennsylvania, 1952-1966.
Box 9 Folder 8
Tocantins, Leandro M. and Louis A. Kazal. Blood Coagulation, Hemorrhage, and Thrombosis, 2nd Ed. (re: Reviews of book and correspondence.), 1963-1964.
Box 9 Folder 9
Grune and Stratton, Incorporated - correspondence; Leandro M. Tocantins' "Method Book"; Dr. Henry Stratton - correspondence (re: Tocantins' "Method Book."), 1965-1971.
Box 9 Folder 10
Leandro M. Tocantins (reprints); Cardeza Institute, 1930-1950, 1973.
Box 9 Folder 11
Fibrinogen Research Review; Thomas Jefferson Medical College, Philadelphia, Pennsylvania; Fractionation of plasma (progress reports); Kunitz basic trypsin inhibitor in crystalline ribonuclease, 1957-1966, 1976.
Box 9 Folder 12
Fibrinogen Sample, 1963.
Box 9 Folder 13
Physical Location

Relocated to the artifacts collection.

Louis A. Kazal Reprints, 1962-1975.
Box 9 Folder 14
Louis A. Kazal - Brief reviews of authors (1942-1975); Phospholipid complexes (Incl. progress reports.); Comparison of phospholipid and cholesterol values in normal and hemophilic patients; Louis A. Kazal - Annual Faculty Professional Activities Reports; Louis A. Kazal - Publications; Final decisions of biological development research (7-14-53), 1942-1975.
Box 9 Folder 15

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