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Charles-Edouard Brown-Séquard papers

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Held at: Historical Medical Library of The College of Physicians of Philadelphia [Contact Us]19 S. 22nd Street, Philadelphia, PA 19103

This is a finding aid. It is a description of archival material held at the Historical Medical Library of The College of Physicians of Philadelphia. Unless otherwise noted, the materials described below are physically available in their reading room, and not digitally available through the web.

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Charles Edouard Brown Sequard, physiologist, was born on 8 April 1817 on Mauritius. He was married three times: to Ellen Fletcher (d. 1868) by whom he had one son; in 1873 to Maria R. Carlisle (d. 1875) by whom he had one daughter; and in 1878 to Elizabeth Emma Dakin. Brown Sequard died on 1 April 1894.

Brown Sequard received a bachelor of letters and a bachelor of science from the University of Paris, then received an M.D. from the Ecole de Medecine in Paris in 1840. He traveled extensively and held several teaching positions, including professor of physiology at the Medical College of Virginia, 1855, professor of physiology and pathology at Harvard University, 1864-1867, and professor of comparative and experimental pathology at the Ecole de Medecine in Paris, 1869-1871. In 1873, he was practicing in New York, but in 1878 assumed the chair of experimental medicine at the College de France. He also founded the Archives of scientific and practical medicine.

In 1849, Brown Sequard discovered sensory decussation in the spinal cord and worked for most of his life on diseases of the spinal column, nervous system, and muscular system. In the last years of his life, Brown Sequard developed the popular "Methode Sequardienne", advocating the use of an extract of testicular fluid to rejuvenate the body, cure certain diseases, and prolong life.

Brown Sequard was a Fellow of the Royal College of Physicians of London, the Royal Society of England, and the American Academy of Sciences.

This small collection contains three brief holograph manuscripts, 1890-1891, of C. E. Brown Sequard. Two of the manuscripts, "Nouvelles remarques" and "Histoire et critique" concern the therapeutic use of animal testicular extract as an aid to rejuvenation and a specific against diseases such as tuberculosis. The third manuscript, "De la perte de connaissance" concerns epilepsy. All three manuscripts were published, "Nouvelles remarques" in Comptes rendus hebdomadaires des seances et memoires la Societe de Biologie (1890), the other two in Archives de physiologiejnormale et pathologie (1891).

The collection also includes an autographed letter signed by Brown Sequard, 27 December 1890, conveying the three manuscripts to S. Weir Mitchell.

The three Brown Sequard manuscripts were donated to the College of Physicians of Philadelphia by S. Weir Mitchell of Philadelphia on 13 January 1891. On 27 December 1890, Brown Sequard himself sent the manuscripts to Mitchell, apparently at the latter's request, specifically for presentation to the College.

Publisher
Historical Medical Library of The College of Physicians of Philadelphia

Collection Inventory

C. E. Brown Sequard [ALS], Nice, France, to S. Weir Mitchell, Philadelphia, Pa., 27 December 1890.
Nouvelles remarques sur le suc testiculaire, circa 1890.
Histoire et critique : l'expose de faits nouveaux montrant la puissance de liquide testiculaire contre certaines maladies et en particulaire la tuberculose pulmonaire, circa 1891.
De la perte de connaissance dans l'epilepsie apres l'ablation du ganglion cervical superieur du nerf grand sympatique des deux cotes chez l'homme et chez le cobaye, circa 1891.

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